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鵝去氧膽酸

分析標(biāo)準(zhǔn)品,HPLC≥98%

Chenodeoxycholic acid

CAS號：474-25-9

分子式：C24H40O4

分子量：392.58

MDL：MFCD00064142

別名：脫氧鵝膽酸；鵝脫氧膽酸；3α,7α-二羥基膽質(zhì)酸；3α,7α-二羥基-5-β-膽烷酸

產(chǎn)品介紹

鵝去氧膽酸是一種疏水初級膽汁酸，能夠活化核受體 FXR，該受體與膽固醇代謝有關(guān)。 生物活性：
Chenodeoxycholic Acid 是一種疏水初級膽汁酸，能夠活化核受體 FXR，該受體與膽固醇代謝有關(guān)。鵝去氧膽酸（CDCA）和脫氧膽酸（DCA）均能抑制11 beta HSD2，IC50值分別為22mM和38mM，并引起皮質(zhì)醇依賴性核易位，增加鹽皮質(zhì)激素受體（MR）的轉(zhuǎn)錄活性。鵝去氧膽酸能夠通過激活膜G蛋白偶聯(lián)受體（TGR5）依賴途徑，誘導(dǎo)細(xì)胞周期蛋白d1蛋白和mRNA表達(dá)的顯著增加，從而刺激Ishikawa細(xì)胞的生長。鵝去氧膽酸（CDCA）在培養(yǎng)的人肝母細(xì)胞瘤細(xì)胞系HepG2中誘導(dǎo)低密度脂蛋白受體mRNA水平約為4倍，高密度脂蛋白輔酶A還原酶和高密度脂蛋白輔酶A合成酶的mRNA水平為2倍。氯去氧膽酸誘導(dǎo)的ISC（≥67%）被布美他尼、Bacl2和囊性纖維化跨膜電導(dǎo)調(diào)節(jié)器（CFTR）抑制劑cftrinh-172抑制。腺苷酸環(huán)化酶抑制劑MDL12330A使鵝去氧膽酸刺激的ISC降低43%，鵝去氧膽酸增加細(xì)胞內(nèi)cAMP濃度。鵝去氧膽酸處理激活c/ebpβ，如其磷酸化、核積累和在hepg2細(xì)胞中的表達(dá)增加所示。Chenodeoxycholic acid增強(qiáng)含有-1.65-kb GSTA2啟動子的構(gòu)建體的熒光素酶基因轉(zhuǎn)錄，該啟動子含有C / EBP反應(yīng)元件（pGL-1651）。鵝去氧膽酸處理激活AMP激活蛋白激酶（AMPK），導(dǎo)致細(xì)胞外信號調(diào)節(jié)激酶1/2（ERK1/2）激活，實驗結(jié)果證明了使用AMPKα的顯性負(fù)突變體和化學(xué)抑制劑。

熔點：165-167℃

沸點：547.1 ℃ at 760 mmHg

比旋光度：12 o (c=1, CHCl3)

外觀：白色粉末

溶解性：幾乎不溶于水，易溶于乙醇、冰乙酸、微溶于氯仿。

敏感性：對光敏感

儲存條件：2-8℃

注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

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