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苦參堿

分析標(biāo)準(zhǔn)品,HPLC≥98%

Matrine

CAS號：519-02-8

分子式：C15H24N2O

分子量：248.36

MDL：MFCD00210527

產(chǎn)品介紹

 Matrine (Matridin-15-one) 是一種在槐屬植物中發(fā)現(xiàn)的生物堿，可作為 kappa 阿片受體和 u-受體激動劑。Matrine 具有多種藥理作用，包括抗癌、抗氧化應(yīng)激、抗炎和抗凋亡作用，可用于人類非小細(xì)胞肺癌、肝癌、甲狀腺乳頭狀癌和急性腎損傷 (AKI) 等疾病的研究。

熔點(diǎn)：77 ℃

沸點(diǎn)：396.7 ℃ at 760 mmHg

比旋光度：(C=1, EtOH)+33

外觀：針狀或棱狀結(jié)晶

溶解性：DMSO:≥50mg/mL(201.32mM)

H2O:20mg/mL(80.53mM;Needultrasonic)

儲存條件：2-8℃

注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)(60篇)

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58. [IF=4.9] Bo Yang et al."A liquid chromatography-tandem mass spectrometry method to determine total matrine residues in edible porcine tissues and its application in a tissue residue depletion study."MICROCHEMICAL JOURNAL.2024 Nov;:112139

57. [IF=5.3] Peijie Wang et al."Potential application of matrine microneedles for the treatment of atopic dermatitis in joint skin."INTERNATIONAL JOURNAL OF PHARMACEUTICS.2025 Jan;668:124992

56. [IF=2.8] Zhuoni Liu et al."Eutectic Solvents Based on Matrine and Fatty Acids as Solubility and Stability Enhancers of Curcumin."JOURNAL OF PHYSICAL CHEMISTRY B.2025;XXXX(XXX):XXX-XXX

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40. [IF=2.13] Xinfeng Chang et al."Matrine inhibits hepatocellular carcinoma cell malignancy through the circ_0013290/miR-139-5p/MMP16 pathway."HISTOLOGY AND HISTOPATHOLOGY.2022 Dec 14;18574

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35. [IF=2.1] Jikun Du et al."Matrine exerts anti?breast cancer activity by mediating apoptosis and protective autophagy via the AKT/mTOR pathway in MCF?7 cells."Mol Med Rep. 2020 Nov;22(5):3659-3666

34. [IF=2.447] Guanglei Wang et al."Matrine ameliorates the inflammatory response and lipid metabolism in vascular smooth muscle cells through the NF?κB pathway."Exp Ther Med. 2021 Nov;22(5):1-8

33. [IF=4.268] Qing Zhao et al."The water extract of Sophorae tonkinensis Radix et Rhizoma alleviates non-alcoholic fatty liver disease and its mechanism."Phytomedicine. 2020 Oct;77:153270

32. [IF=4.932] Sihao Zheng et al."Combination of matrine and tacrolimus alleviates acute rejection in murine heart transplantation by inhibiting DCs maturation through ROS/ERK/NF-κB pathway."Int Immunopharmacol. 2021 Dec;101:108218

31. [IF=1.448] Wang  Xie et al."Matrine inhibits the proliferation and migration of lung cancer cells through regulation of the protein kinase B/glycogen synthase kinase?3β signaling pathways."Exp Ther Med. 2018 Aug;16(2):723-729

30. [IF=3.943] Kangfeng Jiang et al."Matrine alleviates Staphylococcus aureus lipoteichoic acid-induced endometritis via suppression of TLR2-mediated NF-κB activation."Int Immunopharmacol. 2019 May;70:201

29. [IF=4.411] Jifeng Gu et al."Application of High-Performance Liquid Chromatography Coupled with Linear Ion Trap Quadrupole Orbitrap Mass Spectrometry for Qualitative and Quantitative Assessment of Shejin-Liyan Granule Supplements."Molecules. 2018 Apr;23(4):884

28. [IF=5.81] Shang  Xiaofei et al."The Anti-diarrheal Activity of the Non-toxic Dihuang Powder in Mice."Front Pharmacol. 2018 Sep;0:1037

27.  Valkó, Klára. "Application of high-performance liquid chromatography based measurements of lipophilicity to model biological distribution." Journal of chromatography A 1037.1-2 (2004): 299-310.https:##doi.org/10.1016/j.chroma.2003.10.084

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5.  陽麗梅, 黃旭慧, 曹娃,等. 苦參堿對α-萘異硫氰酸酯誘導(dǎo)的大鼠膽汁淤積性肝損傷的作用[J]. 中國藥學(xué)雜志, 2018, 53(010):783-787.

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1.  陳天朝  于蘭蘭  劉瑞霞 等. 不同物料參數(shù)及配比對模型丸劑體外溶出的影響[J]. 中華中醫(yī)藥學(xué)刊  2017  035(011):2899-2902.

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